Applies to the following strengths: 15 g/60 mL. Free E-newsletter Subscribe to Housecall. Sodium polystyrene sulfonate (SPS) is a cross-linked polymer whose reactive sulfonic groups exchange preloaded sodium (Na) for another cation. In neonates, sodium polystyrene sulfonate should not be given by the oral route. Because many drugs are excreted in human milk, caution should be exercised when Sodium polystyrene sulfonate for suspension is administered to a nursing woman. OBJECTIVE To determine whether SPS is effective in reducing serum potassium in general medical patients after a single oral dose. In neonates, Sodium Polystyrene Sulfonate, USP should not be given by the oral route. The effectiveness of sodium polystyrene sulfonate in pediatric patients has not been established. Background . Take this … Usually, the dose of sodium polystyrene sulfonate is between 15 g (60 mL) to 60 g (240 mL), and each 15 g of sodium polystyrene sulfonate can bind 15 mEq of potassium. See complete prescribing information. Administered orally or rectally, the resin can effectively reduce serum potassium concentrations in the neonate as well as the elderly. This drug should not be mixed … Medically reviewed by Drugs.com. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Sodium polystyrene sulfonate and its brand-name products all come as a powder. Sections. The use of sodium polystyrene sulfonate in decreasing serum potassium has recently been questioned due to the lack of documented effectiveness. This powder is mixed with water to create a liquid solution that you can drink. A retrospective cohort analysis of all hospitalized patients who received sodium polystyrene sulfonate over four months was performed. The effectiveness of sodium polystyrene sulfonate in pediatric patients has not been established. Some products contain sorbitol to prevent constipation. Which of the following considerations is the nurses priority? Before Using Subjects will be randomized to one of two treatment arms: 30 g of placebo or SPS to be taken orally once daily for seven days. Sodium polystyrene sulfonate is a cation exchange resin used in the treatment of nonlife-threatening hyperkalemia. Binds with potassium in the intestines to help excrete it from the body more rapidly. Serum potassium level 4.1 mEq/L. BACKGROUND Sodium polystyrene sulfonate (SPS) is a potassium-binding resin that is commonly used to treat mild hyperkalemia. They are also used to remove potassium, calcium, and sodium from solutions in technical applications.. Common side effects include loss of appetite, gastrointestinal upset, constipation, and low blood calcium. It is not known whether this drug is excreted in human milk. Sodium polystyrene sulfonate may decrease your absorption of other medications. Which of the following findings indicates effectiveness of the medication? Methods . Hypersensitivy to sodium polystyrene sulfonate. The use of sodium polystyrene sulfonate in decreasing serum potassium has recently been questioned due to the lack of documented effectiveness. Hypokalemia Obst bowel dx Oral admin in neonates peripheral edema, hypokalemia, hypernatermia, hypomagnesemia, metabloc alkalosis, weight gain lower potassium levels Monitor response of symptoms of hyperalemia (fatigue,muscle weakness,par- esthesia, confusion, dyspnea, peaked T waves, depressed ST segments, prolonged QT segments, widened … Background: Sodium polystyrene sulfonate (SPS) is a potassium-binding resin that is commonly used to treat mild hyperkalemia. Methods. In both children and neonates particular care should be observed with rectal administration, as excessive dosage or inadequate dilution could result in impaction of the resin. In both children and neonates particular care should be observed with rectal administration, as excessive dosage or inadequate dilution could result in impaction of the resin. However, there is limited evidence supporting its effectiveness in the short-term management of hyperkalemia. In neonates, sodium polystyrene sulfonate should not be given by the oral route. Sodium polystyrene sulfonate is not absorbed from the gastrointestinal tract. Few studies have investigated the dose-response of SPS. Effects generally take hours to days. However, there is limited evidence supporting its effectiveness in the short-term management of hyperkalemia. Average adult dose: 15 g (approximately 4 level teaspoons) one to four time daily in water. Disease process. Most of this action occurs in the large intestine, which excretes potassium ions to a greater degree than does the small intestine. The effectiveness of sodium polystyrene sulfonate in pediatric patients has not been established. This medicine is available only with your doctor's prescription. Last updated on April 4, 2019. sodium polystyrene sulfonate, USP. Monitor for intestinal necrosis if sorbitol is added. }, author={Josh Batterink and Jane Lin and Sarah Hin Mui Au-Yeung and Tara A. Cessford}, journal={The Canadian journal of hospital pharmacy}, year={2015}, … Recently, the safety and efficacy of SPS have come into question based on multiple reported cases of bowel necrosis associated with SPS administration. Nursing Mothers. As a result of the concentrations of Na + and K + along the gastrointestinal (GI) lumen, the single favourable site for Na + –K + exchange is the colon . In both children and neonates particular care should be observed with rectal administration, as excessive dosage or inadequate dilution could result in impaction of the resin. Sodium Polystyrene Sulfonate Powder, for Suspension is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3 Proper Use. Introduction. Drug information provided by: IBM Micromedex. Sodium content approximately 60 mEq per 15 g. Suspension should be freshly prepared and … Sodium Polystyrene Sulfonate Dosage. A charge nurse is preparing to make a room assignment for a newly admitted school-age child. Unformatted text preview: ACTIVE LEARNING TEMPLATE: Medication Jordan Williams STUDENT NAME_____ Sodium Polystyrene Sulfonate (Kayexalate) MEDICATION_____ REVIEW MODULE CHAPTER_____ exchange resins CATEGORY CLASS__cationic _____ PURPOSE OF MEDICATION Expected Pharmacological Action Binds potassium ions in the GI lumen, increasing fecal potassium … Sodium polystyrene sulfonate (SPS) is a cation exchange resin used for the treatment of hyperkalemia. Sodium Polystyrene Sulfonate (Oral Route) Print. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. A nurse is assessing an adolescent who received a sodium polystyrene sulfonate enema. Objective: To quantify the change in serum potassium after 15-, 30-, and 60-g oral and 30-g rectal doses of SPS. Discontinue sodium polystyrene sulfonate if patient becomes constipated. Polystyrene sulfonates are a group of medications used to treat high blood potassium. The change in serum potassium was noted over a period of 24 hours. Read package insert. Background: Hyperkalemia occurs frequently in an inpatient setting, for which sodium polystyrene sulfonate (SPS) is a common treatment modality.